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Graded isavuconazole introduction in a patient with voriconazole allergy
Author(s) -
Morales Megan K.,
Harris Ché,
Shoham Shmuel
Publication year - 2017
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12772
Subject(s) - voriconazole , medicine , angioedema , azole , allergy , aspergillosis , posaconazole , dermatology , antifungal , triazole , intensive care medicine , immunology , chemistry , organic chemistry
Triazole antifungal drugs may rarely cause serious allergic reactions including angioedema. No standardized tests are available to predict cross‐reactivity within the azole class and little guiding information exists on whether to change therapy within the class or to another class after a serious allergic reaction. Herein we report the first successful use, to our knowledge, of graded isavuconazole introduction for treatment of aspergillosis in a liver transplant recipient with severe voriconazole allergy.