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Risk factors and long‐term outcomes of parvovirus B19 infection in kidney transplant patients
Author(s) -
Baek Chung Hee,
Kim Hyosang,
Yang Won Seok,
Han Duck Jong,
Park SuKil
Publication year - 2017
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12754
Subject(s) - parvovirus , medicine , odds ratio , kidney transplantation , gastroenterology , confidence interval , transplantation , parvoviridae , kidney , immunology , virus
Background Parvovirus B19 is a small, non‐enveloped, single‐stranded DNA virus with a special affinity for the erythroid progenitor cells of the bone marrow. The first case of parvovirus B19 infection in a kidney transplant recipient ( KTR ) was reported in 1986. Data on the risk factors and specific clinical characteristics of parvovirus B19 infection remain insufficient. Methods We screened 602 KTR s for parvovirus B19 infection using parvovirus B19 polymerase chain reaction ( PCR ) from January 1990 to April 2016, and the clinical characteristics of patients with positive results were compared to those of age‐ and gender‐matched patients with negative PCR results. Results A total of 39 KTR s tested positive for parvovirus B19, and they were compared to 78 age‐ and gender‐matched patients among 563 KTR s who had negative PCR results. In all, 89.7% of positive cases were reported within the first year after kidney transplantation. In multivariate analyses, deceased‐donor kidney transplantation (odds ratio [ OR ] 9.067, 95% confidence interval [ CI ] 1.668‐49.275, P = .011), use of tacrolimus ( OR 3.607, 95% CI 1.024‐12.706, P = .046), PCR test within 1 year of kidney transplantation ( OR 12.456, 95% CI 2.674‐58.036, P = .001), and hemoglobin levels ( OR 0.559, 95% CI 0.351‐0.889, P = .014) showed significant correlations with parvovirus B19 infection. Graft survival did not differ between the two groups during the follow‐up period of 111.68 ± 54.54 months ( P = .685 by log‐rank test). Conclusion The identification of factors related to positive parvovirus B19 PCR results may promote the early detection of parvovirus B19 infection. Further studies are needed to elucidate the characteristics of parvovirus B19 infection in kidney transplantation.