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Relationship between the risk factors for human papillomavirus infection and lower genital tract precursor lesion and cancer development in female transplant recipients
Author(s) -
Oliveira Martins Caroline Alves,
Do Val Guimarães Isabel Cristina Chulvis,
Velarde Luis Guillermo Coca
Publication year - 2017
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12714
Subject(s) - medicine , hpv infection , vaccination , logistic regression , sex organ , human papillomavirus , cancer , lesion , hpv vaccines , oncology , gynecology , cervical cancer , immunology , pathology , biology , genetics
Abstract Background This study aimed to analyze the relationship between the several risk factors for human papillomavirus ( HPV ) infection and its persistence and to assess the prevalence of the lower genital tract precursor lesions, cancer, and HPV infection in female transplant recipients, besides the most prevalent HPV types. Methods The methodology adopted was a cross‐sectional study with a random sample of 61 patients. Results The results indicated 10 cases (16.4%) of lesions, 54.5% of the overall prevalence of HPV infection, and HPV 16 was the most common high‐risk HPV type, followed by HPV 51/53/70. A multiple logistic regression was done and hormone use presented a statistically significant association with high‐risk HPV infection ( P =.037). No statistically significant association was identified for the set of all factors with the lesions studied. Conclusions The high prevalence of HPV infection and its precursor lesions confirmed the importance of differential screening and follow‐up of transplanted patients. Condom use must be encouraged. The study result also confirmed the importance of knowledge of the viral type, in order to analyze the impact of HPV immunization, particularly against HPV types that are not 16/18. The reasonable rate of other genotypes, besides the vaccine types, should be considered to evaluate vaccination strategies.