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High clinical suspicion of donor‐derived disease leads to timely recognition and early intervention to treat solid organ transplant‐transmitted lymphocytic choriomeningitis virus
Author(s) -
Mathur Gagan,
Yadav Kunal,
Ford Bradley,
Schafer Ilana J.,
Basavaraju Sridhar V.,
Knust Barbara,
Shieh WunJu,
Hill Sam,
Locke Garret D.,
Quinlisk Patricia,
Brown Shelley,
Gibbons Ardith,
Can Deborah,
Kuehnert Matthew,
Nichol Stuart T.,
Rollin Pierre E.,
Ströher Ute,
Miller Rachel
Publication year - 2017
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12707
Subject(s) - lymphocytic choriomeningitis , medicine , immunosuppression , ribavirin , organ transplantation , transplantation , disease , immunology , virus , intensive care medicine , immune system , hepatitis c virus , cd8
Despite careful donor screening, unexpected donor‐derived infections continue to occur in organ transplant recipients ( OTR s). Lymphocytic choriomeningitis virus ( LCMV ) is one such transplant‐transmitted infection that in previous reports has resulted in a high mortality among the affected OTR s. We report a LCMV case cluster that occurred 3 weeks post‐transplant in three OTR s who received allografts from a common organ donor in March 2013. Following confirmation of LCMV infection at Centers for Disease Control and Prevention, immunosuppression was promptly reduced and ribavirin and/or intravenous immunoglobulin therapy were initiated in OTR s. The liver recipient died, but right kidney recipients survived without significant sequelae and left kidney recipient survived acute LCMV infection with residual mental status deficit. Our series highlights how early recognition led to prompt therapeutic intervention, which may have contributed to more favorable outcome in the kidney transplant recipients.