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A retrospective study to describe the epidemiology and outcomes of opportunistic infections after abdominal organ transplantation
Author(s) -
Helfrich Mia,
Dorschner Peter,
Thomas Kathryn,
Stosor Valentina,
Ison Michael G.
Publication year - 2017
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12691
Subject(s) - medicine , organ transplantation , intensive care medicine , epidemiology , transplantation , retrospective cohort study , medline , political science , law
Background Most epidemiologic studies of opportunistic infections ( OI ) following abdominal organ transplantation are derived prior to the era of contemporary immunosuppression and prophylaxis. These studies suggest that most OI occur within the first 6 months post transplant. Method In this single‐center, retrospective cohort study, we describe the epidemiology of OI in 359 consecutive abdominal organ transplant recipients, in the era of contemporary prophylaxis practices and alemtuzumab induction in kidney and simultaneous pancreas‐kidney transplant recipients. Results Ninety patients (25.1%) developed OI , with 53.3% of these occurring beyond 6 months. The most common OI were BK polyomavirus nephropathy (5.0%), cytomegalovirus (10.2%), varicella zoster virus (4.4%), and herpes simplex virus (1.1%), which typically occurred after discontinuation of antiviral prophylaxis, and C lostridium difficile infections (7.8%). Conclusion OI had no impact on patient or graft survival at 12 months post transplant. In the era of contemporary immunosuppression and prophylaxis, a significant proportion of OI occur beyond 6 months. Additional strategies may be important to reduce the incidence of such late‐onset infections.