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Stabilization of renal function after the first year of follow‐up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus‐associated nephropathy
Author(s) -
SimardMeilleur MarieChristine,
BodsonClermont Paule,
StLouis Gilles,
Pâquet Michel R.,
Girardin Catherine,
Fortin MarieChantal,
Cardinal Héloïse,
Hébert MarieJosée,
Lévesque Renée,
Renoult Edith
Publication year - 2017
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12681
Subject(s) - immunosuppression , bk virus , medicine , polyomavirus infections , viremia , nephropathy , kidney transplantation , transplantation , urology , renal function , kidney , biopsy , creatinine , gastroenterology , surgery , immunology , virus , endocrinology , diabetes mellitus
Background BK polyomavirus virus ( BKP yV) screening and immunosuppression reduction effectively prevent graft loss due to BKP yV‐associated nephropathy ( BKPVAN ) during the first year after transplantation. The aim of our study was to evaluate the impact of this infection during longer follow‐up periods. Methods We reviewed the outcome of our screening and immunosuppression reduction protocol in 305 patients who received a kidney transplant between March 2008 and January 2013. Quantitative BKP yV DNA surveillance in plasma was performed at 1, 2, 3, 6, 9, and 12 months after transplantation. Patients with significant viremia and/or biopsy‐proven BKPVAN were treated with immunosuppression reduction and leflunomide. Results During the first post‐transplant year, 24 patients (7.9%) developed significant viremia at a median time of 95 days, and 18 patients had BKPVAN ; 23 of the 24 (7.5%) were treated according to our protocol (group BKV +); 225 patients (73.8%) did not develop any BK viremia (group BKV −). Allograft function was similar in both groups at 1 month post transplantation ( P =.87), but significantly worse at 1 year in the BKV + group ( P =.002). Thereafter, kidney function stabilized in the BKV + group and no differences in patient and graft survival were seen between the groups after a median follow‐up of 4 years. Conclusions We confirm the early occurrence of BKP yV replication after transplantation and the short‐term decline in renal function. However, early detection of BKP yV replication, prompt diagnosis, and reduction in immunosuppression may offer long‐term benefits for graft function.