Premium
Pseudozyma and other non‐ Candida opportunistic yeast bloodstream infections in a large stem cell transplant center
Author(s) -
Pande Anupam,
Lemuel R.,
Romee Rizwan,
Santos Carlos A. Q.
Publication year - 2017
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12664
Subject(s) - micafungin , fungemia , echinocandin , medicine , voriconazole , echinocandins , bloodstream infection , microbiology and biotechnology , candida albicans , intensive care medicine , fluconazole , antifungal , immunology , caspofungin , mycosis , biology , dermatology
Non‐ Candida opportunistic yeasts are emerging causes of bloodstream infection ( BSI ) in immunocompromised hosts. However, their clinical presentation, management, and outcomes in stem cell transplant ( SCT ) recipients are not well described. We report the first case to our knowledge of Pseudozyma BSI in a SCT recipient. He had evidence of cutaneous involvement, which has not been previously described in the literature. He became infected while neutropenic and receiving empiric micafungin, which is notable because Pseudozyma is reported to be resistant to echinocandins. He was successfully treated with the sequential use of liposomal amphotericin B and voriconazole. A review of the literature revealed nine reported instances of Pseudozyma fungemia. We performed a retrospective review of 3557 SCT recipients at our institution from January 2000 to June 2015 and identified four additional cases of non‐ Candida yeast BSI s. These include two with Cryptococcus , one with Trichosporon , and one with Saccharomyces . Pseudozyma and other non‐ Candida yeasts are emerging pathogens that can cause severe and disseminated infections in SCT recipients and other immunocompromised hosts. Clinicians should have a high degree of suspicion for echinocandin‐resistant yeasts, if patients develop breakthrough yeast BSI s while receiving echinocandin therapy.