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Successful renal retransplantation after graft loss from BK polyomavirus infection in a human immunodeficiency virus‐positive patient
Author(s) -
Barthélemy Aurore,
Bouvier Nicolas,
Verdon Renaud,
Chatelet Valérie,
Hurault de Ligny Bruno
Publication year - 2016
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12615
Subject(s) - viremia , medicine , bk virus , antibody , mycophenolic acid , tacrolimus , transplantation , polyomavirus infections , kidney transplantation , virology , immunology , human immunodeficiency virus (hiv) , nephropathy , diabetes mellitus , endocrinology
Abstract We report the case of a human immunodeficiency virus‐seropositive patient whose initial kidney transplant failed because of BK polyomavirus‐induced nephropathy, and who underwent a second transplantation 3 years later. BK viruria was detected 1 day after transplantation. After 1 month, BK viremia developed along with a donor‐specific antibody. After decreasing tacrolimus and mycophenolic acid and 2 courses of intravenous immunoglobulins, BK viremia and donor‐specific antibody permanently disappeared, with stable renal function.