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Incidence of BK polyomavirus infection after kidney transplantation is independent of type of immunosuppressive therapy
Author(s) -
Radtke Josephine,
Dietze Nina,
Fischer Lutz,
Achilles EikeGert,
Li Jun,
Scheidat Silke,
Thaiss Friedrich,
Nashan Bjoern,
Koch Martina
Publication year - 2016
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12611
Subject(s) - medicine , immunosuppression , basiliximab , bk virus , calcineurin , transplantation , kidney transplantation , everolimus , mycophenolic acid , viremia , polyomavirus infections , incidence (geometry) , immunology , gastroenterology , antibody , physics , optics
Abstract Background BK polyomavirus ( BKV ) infection and BKV nephropathy ( BKVN ) are risk factors for allograft function and survival. Methods We retrospectively analyzed BK viremia and BKVN in 348 patients who received a kidney transplantation donated after brain death (n=232) or living donation (n=116) between 2008 and 2013. A total of 266 patients were treated with standard immunosuppression consisting of basiliximab induction, calcineurin inhibitor ( CNI ), and mycophenolic acid ( MPA , n=219) or everolimus (n=47); 82 patients received more intense immunosuppression with lymphocyte depletion, CNI and MPA (n=38) or everolimus (n=44). Results BK viremia occurred in 33 (9.5%) patients in the first year and in 7 (2.0%) recipients in the second year after transplantation. BKVN occurred in 4 (1.1%) patients in the first year. Donor and recipient age, diabetes, previous transplantation, and type of transplantation (donated after brain death vs living donation) were not risk factors ( P >.05). BK incidence did not differ depending on induction or maintenance immunosuppression. Conclusion Incidence of BK viremia is independent of recipient characteristics, type of transplantation as well as induction and maintenance immunosuppression.