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An emerging opportunistic infection: fatal astrovirus ( VA 1/ HMO ‐C) encephalitis in a pediatric stem cell transplant recipient
Author(s) -
Lum Su Han,
Turner Andrew,
Guiver Malcolm,
Bonney Denise,
Martland Timorthy,
Davies Emma,
Newbould Melanie,
Brown Julianne,
Morfopoulou Sofia,
Breuer Judith,
Wynn Robert
Publication year - 2016
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12607
Subject(s) - astrovirus , medicine , encephalitis , virology , polymerase chain reaction , immunology , bone marrow transplantation , bone marrow transplant , virus , bone marrow , biology , gene , rotavirus , biochemistry
Neuroinvasive astrovirus ( VA 1‐ HMO ‐C) is an emerging life‐threatening infection in immunocompromised hosts. We describe an 8‐month‐old child who died of VA 1/ HMO ‐C encephalitis following bone marrow transplantation. The diagnosis was only made post‐mortem using RNA deep sequencing of the brain. Repeat analysis of the post‐mortem brain tissue using polymerase chain reaction specific primers for VA 1/ HMO ‐C was positive. Astrovirus VA 1/ HMO ‐C should be included in the evaluation of patients with similar encephalitis.