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Post‐prophylaxis Toxoplasma chorioretinitis following donor–recipient mismatched liver transplantation
Author(s) -
Webb G.J.,
Shah H.,
David M.D.,
Tiew S.,
Beare N.,
Hirschfield G.M.
Publication year - 2016
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12589
Subject(s) - medicine , seroconversion , toxoplasmosis , serology , transplantation , chorioretinitis , immunology , liver transplantation , organ transplantation , antibody , virology , surgery , ophthalmology
Abstract Toxoplasmosis may be transferred by organ transplantation. The most common clinical presentation is with multisystem disease, although isolated ocular toxoplasmosis has been described. Many centers have suggested that universal use of co‐trimoxazole prophylaxis obviates the need for specific T oxoplasma testing. We report a case of donor‐acquired ocular toxoplasmosis after liver transplantation despite co‐trimoxazole prophylaxis. The diagnosis was confirmed by T oxoplasma polymerase chain reaction assay in conjunction with seroconversion. The fact that the infection was donor acquired was confirmed by serological mismatch and the absence of sporozoite‐specific antigen antibody in the recipient.