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Visceral leishmaniasis in a lung transplant recipient: usefulness of highly sensitive real‐time polymerase chain reaction for preemptive diagnosis
Author(s) -
Opota O.,
Balmpouzis Z.,
Berutto C.,
KaiserGuignard J.,
Greub G.,
Aubert J.D.,
Prod'hom G.,
Manuel O.,
Jaton K.
Publication year - 2016
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12585
Subject(s) - medicine , polymerase chain reaction , visceral leishmaniasis , real time polymerase chain reaction , lung , leishmaniasis , immunology , pathology , genetics , gene , biology
We report the case of a lung transplant recipient in whom the diagnosis of visceral leishmaniasis ( VL ) was made by detection of parasites in a peripheral blood smear when the parasite load already reached 8.9 × 10 3 parasites/mL. We demonstrated that the VL diagnosis could have been done months before the development of symptoms by the use of L eishmania ‐specific real‐time polymerase chain reaction ( PCR ), suggesting the role of preemptive PCR ‐based diagnosis in transplant recipients at risk for VL .