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Successful treatment of a disseminated infection with extensively drug‐resistant K lebsiella pneumoniae in a liver transplant recipient with a fosfomycin‐based multidrug regimen
Author(s) -
Mills J.P.,
Wilck M.B.,
Weikert B.C.,
Porrett P.M.,
Timko D.,
Alby K.,
Bonomo R.A.,
Blumberg E.A.
Publication year - 2016
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12578
Subject(s) - fosfomycin , medicine , colistin , multiple drug resistance , regimen , antibiotics , adjunctive treatment , drug , drug resistance , klebsiella pneumoniae , microbiology and biotechnology , pharmacology , biology , biochemistry , escherichia coli , gene
Donor‐derived infections with multidrug‐resistant gram‐negative bacteria are associated with poor outcomes, in part because of limited treatment options. Here, we describe a case of donor‐derived, disseminated infection with colistin‐resistant, carbapenemase‐producing K lebsiella pneumoniae in a liver transplant recipient that was cured with addition of intravenous fosfomycin to a multidrug regimen, in conjunction with aggressive surgical source control. Intravenous fosfomycin represents a promising adjunctive agent for use in treatment of extensively drug‐resistant infections in immunocompromised hosts.