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A unique presentation of acute liver failure from herpes simplex virus hepatitis
Author(s) -
Gutierrez C.,
Kebriaei P.,
Turner K.A.,
Yemelyanova A.,
ArizaHeredia E.J.,
Foo W.C.
Publication year - 2016
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12556
Subject(s) - medicine , herpes simplex virus , fulminant , presentation (obstetrics) , population , fulminant hepatic failure , hepatitis , fulminant hepatitis , liver failure , pediatrics , immunology , virology , gastroenterology , virus , surgery , liver transplantation , transplantation , environmental health
We present the case of a patient, with history of myelodysplastic syndrome and recent bone marrow transplant, who developed fulminant liver failure secondary to herpes simplex virus ( HSV ) hepatitis. His presentation was unique, as findings of liver microabscesses on computed tomography scan have not been described previously in this patient population. Despite initial treatment with acyclovir, he continued to deteriorate, and later sensitivities found the HSV strain to be resistant to acyclovir. HSV hepatitis with secondary liver failure is rare and, without appropriate treatment, its mortality is >80%. Early suspicion and immediate therapy are the keys to improve patient survival.