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Severe cryptococcal‐associated neurological immune reconstitution inflammatory syndrome in a renal transplant recipient treated with adalimumab
Author(s) -
Deshayes S.,
Bouvier N.,
Chatelet V.,
Hurault de Ligny B.,
Dargère S.,
Bonhomme J.,
Béchade C.
Publication year - 2016
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12522
Subject(s) - medicine , immune reconstitution inflammatory syndrome , cryptococcosis , adalimumab , immunology , immune system , kidney transplantation , renal transplant , tumor necrosis factor alpha , kidney , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load
Cryptococcosis is a major concern in organ transplant recipients. A decrease in immunosuppressants following the initiation of antifungal therapy is currently recommended, but can occasionally be complicated by the onset of immune reconstitution inflammatory syndrome ( IRIS ). We report on a case of cryptococcosis in a kidney transplant recipient, compounded by severe neurological IRIS , the outcome of which was unfavorable despite the use of anti‐tumor necrosis factor‐alpha monoclonal antibodies.