Severe cryptococcal‐associated neurological immune reconstitution inflammatory syndrome in a renal transplant recipient treated with adalimumab | Zendy

Deshayes S. | Zendy; Bouvier N. | Zendy; Chatelet V. | Zendy; Hurault de Ligny B. | Zendy; Dargère S. | Zendy; Bonhomme J. | Zendy; Béchade C. | Zendy

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Severe cryptococcal‐associated neurological immune reconstitution inflammatory syndrome in a renal transplant recipient treated with adalimumab

Author(s) -

Deshayes S.,

Bouvier N.,

Chatelet V.,

Hurault de Ligny B.,

Dargère S.,

Bonhomme J.,

Béchade C.

Publication year - 2016

Publication title -

transplant infectious disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.69

H-Index - 67

eISSN - 1399-3062

pISSN - 1398-2273

DOI - 10.1111/tid.12522

Subject(s) - medicine , immune reconstitution inflammatory syndrome , cryptococcosis , adalimumab , immunology , immune system , kidney transplantation , renal transplant , tumor necrosis factor alpha , kidney , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load

Cryptococcosis is a major concern in organ transplant recipients. A decrease in immunosuppressants following the initiation of antifungal therapy is currently recommended, but can occasionally be complicated by the onset of immune reconstitution inflammatory syndrome ( IRIS ). We report on a case of cryptococcosis in a kidney transplant recipient, compounded by severe neurological IRIS , the outcome of which was unfavorable despite the use of anti‐tumor necrosis factor‐alpha monoclonal antibodies.

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