Guillain–Barré syndrome associated with resistant cytomegalovirus infection after face transplantation | Zendy

Alhefzi M. | Zendy; Aycart M.A. | Zendy; Bueno E.M. | Zendy; Kueckelhaus M. | Zendy; Fischer S. | Zendy; Snook R.J. | Zendy; Sharfuddin A.A. | Zendy; Hadad I. | Zendy; Malla P. | Zendy; Amato A.A. | Zendy; Pomahac B. | Zendy; Marty F.M. | Zendy

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Guillain–Barré syndrome associated with resistant cytomegalovirus infection after face transplantation

Author(s) -

Alhefzi M.,

Aycart M.A.,

Bueno E.M.,

Kueckelhaus M.,

Fischer S.,

Snook R.J.,

Sharfuddin A.A.,

Hadad I.,

Malla P.,

Amato A.A.,

Pomahac B.,

Marty F.M.

Publication year - 2016

Publication title -

transplant infectious disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.69

H-Index - 67

eISSN - 1399-3062

pISSN - 1398-2273

DOI - 10.1111/tid.12516

Subject(s) - medicine , cytomegalovirus , cytomegalovirus infections , transplantation , cytomegalovirus infection , guillain barre syndrome , virology , immunology , herpesviridae , virus , human cytomegalovirus , viral disease

A 39‐year‐old male, who received a facial allograft (cytomegalovirus [ CMV ] donor‐seropositive, recipient‐seronegative), developed multidrug‐resistant CMV infection despite valganciclovir prophylaxis (900 mg/day) 6 months post transplantation. Lower extremity weakness with upper and lower extremity paresthesias developed progressively 11 months post transplantation, coinciding with immune control of CMV . An axonal form of Guillain–Barré syndrome was diagnosed, based on electrophysiological evidence of a generalized, non‐length‐dependent, sensorimotor axonal polyneuropathy. Treatment with intravenous immunoglobulin led to complete recovery without recurrence after 6 months.

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