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Guillain–Barré syndrome associated with resistant cytomegalovirus infection after face transplantation
Author(s) -
Alhefzi M.,
Aycart M.A.,
Bueno E.M.,
Kueckelhaus M.,
Fischer S.,
Snook R.J.,
Sharfuddin A.A.,
Hadad I.,
Malla P.,
Amato A.A.,
Pomahac B.,
Marty F.M.
Publication year - 2016
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12516
Subject(s) - medicine , cytomegalovirus , cytomegalovirus infections , transplantation , cytomegalovirus infection , guillain barre syndrome , virology , immunology , herpesviridae , virus , human cytomegalovirus , viral disease
A 39‐year‐old male, who received a facial allograft (cytomegalovirus [ CMV ] donor‐seropositive, recipient‐seronegative), developed multidrug‐resistant CMV infection despite valganciclovir prophylaxis (900 mg/day) 6 months post transplantation. Lower extremity weakness with upper and lower extremity paresthesias developed progressively 11 months post transplantation, coinciding with immune control of CMV . An axonal form of Guillain–Barré syndrome was diagnosed, based on electrophysiological evidence of a generalized, non‐length‐dependent, sensorimotor axonal polyneuropathy. Treatment with intravenous immunoglobulin led to complete recovery without recurrence after 6 months.