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Successful treatment of cytomegalovirus enteritis after unrelated allogeneic stem cell transplantation by the infusion of ex vivo ‐expanded CD 4 + lymphocytes derived from the recipient's peripheral blood donor cells
Author(s) -
Muto T.,
Takeda Y.,
Tsukamoto S.,
Sakai S.,
Mimura N.,
Ohwada C.,
Takeuchi M.,
Sakaida E.,
Ota S.,
Iseki T.,
Shimizu N.,
Morio T.,
Nakaseko C.
Publication year - 2016
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12487
Subject(s) - medicine , ex vivo , transplantation , cytomegalovirus , stem cell , immunology , enteritis , adoptive cell transfer , refractory (planetary science) , in vivo , t cell , immune system , gastroenterology , virus , herpesviridae , viral disease , biology , genetics , microbiology and biotechnology , astrobiology
Adoptive immunotherapies have been developed for antiviral agent‐refractory cytomegalovirus ( CMV ) disease after stem cell transplantation ( SCT ). However, the application of such strategies is limited, particularly in terms of need for donor cooperation regarding blood sampling and inaccessibility in the setting of cord blood transplantation. Herein, we describe the first successful treatment of antiviral agent‐refractory CMV enteritis after allogeneic SCT by the infusion of ex vivo ‐expanded donor‐derived CD 4 + lymphocytes obtained from the recipient's peripheral blood.