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JC polyomavirus nephropathy confirmed by using an in‐house polymerase chain reaction method
Author(s) -
Querido S.,
Jorge C.,
Sousa H.,
Birne R.,
Matias P.,
Weigert A.,
Adragão T.,
Bruges M.,
Ramos S.,
Santos M.,
Paixão P.,
Curran M.D.,
Machado D.
Publication year - 2015
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12426
Subject(s) - medicine , jc virus , polyomavirus infections , bk virus , polymerase chain reaction , virology , renal function , biopsy , kidney transplantation , nephropathy , renal biopsy , transplantation , pathology , nephritis , real time polymerase chain reaction , virus , progressive multifocal leukoencephalopathy , biology , gene , biochemistry , diabetes mellitus , endocrinology
We report the case of an isolated JC virus ( JCV ) infection, without co‐infection by polyoma BK virus ( BKV ), associated with nephropathy 4 years after kidney transplantation. Clinical suspicion followed the observation of a decrease in estimated glomerular filtration rate ( eGFR ) and a renal allograft biopsy revealing polyomavirus‐associated tubulointerstitial nephritis and positivity for SV 40. An in‐house real‐time polymerase chain reaction assay, targeting the presence of JCV and the absence of BKV in biopsy tissue, confirmed diagnosis. Thirteen months after diagnosis, and following therapeutic measures, eGFR remains stable.