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C hryseobacterium indologenes in four patients with leukemia
Author(s) -
Deng L.,
Li M.F.,
Li Y.H.,
Yang J.L.,
Zhou X.
Publication year - 2015
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12400
Subject(s) - medicine , pneumonia , pseudomonas aeruginosa , leukemia , trimethoprim , microbiology and biotechnology , antibiotics , bacteremia , pathogen , immunology , bacteria , biology , genetics
C hryseobacterium indologenes is a rare opportunistic pathogen causing hospital‐acquired infection. We present 4 patients with leukemia associated with C . indologenes infection. Two of the patients, undergoing peripheral blood allogeneic hematopoietic stem cell transplantation (allo HSCT ) from human leukocyte antigen‐identical sibling donors, died of pneumonia caused by C . indologenes with or without P seudomonas aeruginosa . Blood infection with C . indologenes was found in the other 2 patients during chemotherapy, 1 of which was a central venous catheter‐related bloodstream infection. Both patients were cured with or without the sensitive antibiotic. Three of these 4 isolates were susceptible to trimethoprim‐sulfamethoxazole only in vitro . Although C . indologenes has a weak toxicity, it can be lethal for the super‐immunocompromised patients, such as those treated with allo HSCT .