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Disseminated Bacillus Calmette‐Guérin ( BCG ) infection following allogeneic hematopoietic stem cell transplant in a patient with Bare Lymphocyte Syndrome type II
Author(s) -
AbuArja R.F.,
Gonzalez B.E.,
Jacobs M.R.,
Cabral L.,
Egler R.,
Auletta J.,
Arnold J.,
Cooke K.R.
Publication year - 2014
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12263
Subject(s) - medicine , stem cell , immunology , hematopoietic stem cell , haematopoiesis , hematopoietic stem cell transplantation , microbiology and biotechnology , lymphocyte , transplantation , biology , genetics
We describe the first case, to our knowledge, of disseminated M ycobacterium bovis B acillus C almette‐ G uérin infection in a child with Bare Lymphocyte Syndrome type II after undergoing hematopoietic stem cell transplantation ( HSCT ). The patient presented 30 days post HSCT with fever and lymphadenitis. Lymph node, blood, and gastric aspirates were positive for M . bovis . The patient received a prolonged treatment course with a combination of isoniazid, levofloxacin, and ethambutol. Her course was further complicated by granulomatous lymphadenitis and otitis media associated with M . bovis that developed during immune suppression taper and immune reconstitution. Ultimately, the patient recovered fully, in association with restoration of immune function, and has completed 12 months of therapy.