z-logo
Premium
Transient residence of a seropositive organ is sufficient to transfer human cytomegalovirus to a seronegative recipient
Author(s) -
Lumgair H.A.,
Rolando N.,
O'Beirne J.,
Sharma D.,
Griffiths P.D.
Publication year - 2014
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12205
Subject(s) - viremia , medicine , cytomegalovirus , human cytomegalovirus , immunology , organ transplantation , liver transplantation , pathogenesis , betaherpesvirinae , herpesviridae , virology , transplantation , virus , viral disease
Many aspects of the pathogenesis of human cytomegalovirus ( HCMV ) infection in liver transplantation remain unclear. This study examined the transfer of HCMV from the transient residence of a seropositive organ in seronegative recipients. All subjects receiving >1 orthotopic liver transplant ( LT ) were identified from an LT database. The patients of interest were HCMV ‐seronegative LT recipients who received their first organ from a seropositive donor, and subsequently a second LT from a seronegative donor within 30 days. Of 98 patients identified, 6 met these criteria and 4 developed viremia; in 2 cases, after the seropositive organ was in situ for 28 and 109 h. We can therefore conclude that 28 h is sufficient to allow HCMV to transmit, but the minimum time has not yet been defined.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here