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Transient residence of a seropositive organ is sufficient to transfer human cytomegalovirus to a seronegative recipient
Author(s) -
Lumgair H.A.,
Rolando N.,
O'Beirne J.,
Sharma D.,
Griffiths P.D.
Publication year - 2014
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12205
Subject(s) - viremia , medicine , cytomegalovirus , human cytomegalovirus , immunology , organ transplantation , liver transplantation , pathogenesis , betaherpesvirinae , herpesviridae , virology , transplantation , virus , viral disease
Many aspects of the pathogenesis of human cytomegalovirus ( HCMV ) infection in liver transplantation remain unclear. This study examined the transfer of HCMV from the transient residence of a seropositive organ in seronegative recipients. All subjects receiving >1 orthotopic liver transplant ( LT ) were identified from an LT database. The patients of interest were HCMV ‐seronegative LT recipients who received their first organ from a seropositive donor, and subsequently a second LT from a seronegative donor within 30 days. Of 98 patients identified, 6 met these criteria and 4 developed viremia; in 2 cases, after the seropositive organ was in situ for 28 and 109 h. We can therefore conclude that 28 h is sufficient to allow HCMV to transmit, but the minimum time has not yet been defined.