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Invasive T richosporon infection in solid organ transplant patients: a report of two cases identified using IGS 1 ribosomal DNA sequencing and a review of the literature
Author(s) -
Almeida Júnior J.N.,
Song A.T.W.,
Campos S.V.,
Strabelli T.M.V.,
Del Negro G.M.,
Figueiredo D.S.Y.,
Motta A.L.,
Rossi F.,
Guitard J.,
Benard G.,
Hennequin C.
Publication year - 2014
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12179
Subject(s) - voriconazole , trichosporon , medicine , amphotericin b , microbiology and biotechnology , population , organ transplantation , transplantation , immunology , antifungal , biology , yeast , dermatology , genetics , environmental health
T richosporon species are rare etiologic agents of invasive fungal infection in solid organ transplant ( SOT ) recipients. We report 2 well‐documented cases of T richosporon inkin invasive infection in SOT patients. We also conducted a detailed literature review of T richosporon species infections in this susceptible population. We gathered a total of 13 cases of T richosporon species infections. Any type of organ transplantation can be complicated by T richosporon infection. Bloodstream infections and disseminated infections were the most common clinical presentations. Liver recipients with bloodstream or disseminated infections had poor prognoses. Although the most common species was formerly called T richosporon beigelii , this species name should no longer be used because of the changes in the taxonomy of this genus resulting from the advent of molecular approaches, which were also used to identify the strains isolated from our patients. Antifungal susceptibility testing highlights the possibility of multidrug resistance. Indeed, T richosporon has to be considered in cases of breakthrough infection or treatment failure under echinocandins or amphotericin therapy. Voriconazole seems to be the best treatment option.