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Three cases of donor‐derived pulmonary tuberculosis in lung transplant recipients and review of 12 previously reported cases: opportunities for early diagnosis and prevention
Author(s) -
Mortensen E.,
Hellinger W.,
Keller C.,
Cowan L.S.,
Shaw T.,
Hwang S.,
Pegues D.,
Ahmedov S.,
Salfinger M.,
Bower W.A.
Publication year - 2014
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12171
Subject(s) - medicine , pulmonary tuberculosis , tuberculosis , lung , lung transplantation , intensive care medicine , pathology
Solid organ transplant recipients have a higher frequency of tuberculosis ( TB ) than the general population, with mortality rates of approximately 30%. Although donor‐derived TB is reported to account for <5% of TB in solid organ transplants, the source of M ycobacterium tuberculosis infection is infrequently determined. Methods We report 3 new cases of pulmonary TB in lung transplant recipients attributed to donor infection, and review the 12 previously reported cases to assess whether cases could have been prevented and whether any cases that might occur in the future could be detected and investigated more quickly. Specifically, we evaluate whether opportunities existed to determine TB risk on the basis of routine donor history, to expedite diagnosis through routine mycobacterial smears and cultures of respiratory specimens early post transplant, and to utilize molecular tools to investigate infection sources epidemiologically. Findings On review, donor TB risk was present among 7 cases. Routine smears and cultures diagnosed 4 asymptomatic cases. Genotyping was used to support epidemiologic findings in 6 cases. Conclusion Validated screening protocols, including microbiological testing and newer technologies (e.g., interferon‐gamma release assays) to identify unrecognized M . tuberculosis infection in deceased donors, are warranted.