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Persistent parvovirus B19 infection resulting in red cell aplasia after allogeneic hematopoietic stem cell transplantation
Author(s) -
Koda Y.,
Mori T.,
Kato J.,
Kohashi S.,
Kikuchi T.,
Mitsuhashi T.,
Murata M.,
Uemura T.,
Handa M.,
Okamoto S.
Publication year - 2013
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12155
Subject(s) - medicine , hematopoietic stem cell transplantation , parvovirus , asymptomatic , transplantation , viremia , stem cell , aplasia , pure red cell aplasia , immunology , aplastic anemia , pathology , bone marrow , antibody , virus , biology , genetics
Persistent parvovirus B19 ( PVB ) infection has been reported sporadically in immunocompromised patients including hematopoietic stem cell and solid organ transplant recipients. However, the pathogenesis of persistent infection has yet to be fully elucidated. We report here a patient with multiple myeloma developing red cell aplasia during the hematopoietic recovery after allogeneic hematopoietic stem cell transplantation ( HSCT ) caused by PVB . The patient had already had PVB viremia before transplantation and remained asymptomatic. The route of PVB transmission was considered to be direct contact with the patient's family member with primary PVB infection 1 month before transplantation. Treatment with intravenous immunoglobulin resulted in prompt resolution of anemia. These findings suggest that monitoring of PVB DNA is recommended for patients undergoing HSCT and having contact with individuals with documented PVB infection, even if they are asymptomatic.