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No effect of antifungal compounds on functional properties of human antifungal T‐helper type 1 cells
Author(s) -
Tramsen L.,
Schmidt S.,
Koehl U.,
Huenecke S.,
Latgé J.P.,
Roeger F.,
Schubert R.,
Klingebiel T.,
Lehrnbecher T.
Publication year - 2013
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12089
Subject(s) - posaconazole , caspofungin , voriconazole , antifungal , amphotericin b , fluconazole , medicine , pharmacology , immunology , microbiology and biotechnology , biology
Despite the availability of new antifungal compounds, invasive fungal disease is associated with a high mortality in hematopoietic stem cell transplant ( HSCT ) recipients. A growing body of evidence suggests that T lymphocytes from the T‐helper type 1 (T H 1) play an important role in the antifungal host defense, and preliminary data indicate a potential benefit of infusing donor‐derived antifungal T H 1 cells to HSCT patients suffering from invasive fungal disease. Unfortunately, it is unclear to date whether the function of these cells is affected by concomitantly administered antifungal agents. We therefore analyzed the effects of various concentrations of commonly used antifungal compounds such as amphotericin B, caspofungin, fluconazole, voriconazole, and posaconazole on the functional properties of cultivated human antifungal T H 1 cells. None of the antifungal compounds tested significantly influenced the secretion of interferon‐γ and tumor necrosis factor‐α, and only posaconazole at high concentrations slightly decreased proliferation of antifungal T H 1 cells. Our data indicate that the antifungal agents tested do not significantly affect the functional properties of antifungal T H 1 cells and can therefore be concomitantly administered.