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Multifocal periostitis as a complication of chronic use of voriconazole in a lung transplant recipient
Author(s) -
Tedja R.,
ElSherief A.,
Olbrych T.,
Gordon S.
Publication year - 2013
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12088
Subject(s) - voriconazole , medicine , periostitis , complication , discontinuation , aspergillosis , lung , lung transplantation , surgery , antifungal , transplantation , dermatology , immunology
Fungal infections are common in solid organ transplantation. An increasing number of transplant recipients receive antifungal therapy for prolonged duration owing to invasive fungal infections. Herein, we describe a diagnosis of periostitis as a complication of chronic use of voriconazole in a lung transplant recipient. The patient was diagnosed with probable pulmonary aspergillosis and was treated with oral voriconazole for a total of 9 months. Evidence of multifocal periostitis was observed in the axial and appendicular skeleton. Early recognition of this phenomenon is important to prevent unnecessary tests and procedures. Prompt discontinuation of voriconazole should result in improvement of symptoms.