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S cedosporium prolificans pericarditis and mycotic aortic aneurysm in a lung transplant recipient receiving voriconazole prophylaxis
Author(s) -
Sayah D.M.,
Schwartz B.S.,
Kukreja J.,
Singer J.P.,
Golden J.A.,
Leard L.E.
Publication year - 2013
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12056
Subject(s) - medicine , voriconazole , pericarditis , mycotic aneurysm , lung , intensive care medicine , antifungal , lung transplantation , surgery , aneurysm , dermatology
Despite the adoption of antifungal prophylaxis, fungal infections remain a significant concern in lung transplant recipients. Indeed, some concern exists that such prophylaxis may increase the risk of infection with drug‐resistant fungal organisms. Here, we describe a case of disseminated S cedosporium prolificans infection, presenting as pericarditis, which developed in a lung transplant patient receiving prophylactic voriconazole for 8 months. The epidemiology and clinical presentation of S . prolificans infections are reviewed, and controversies surrounding antifungal prophylaxis and the development of resistant infections are discussed.