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Fecal microbiota transplantation for fulminant C lostridium difficile infection in an allogeneic stem cell transplant patient
Author(s) -
Neemann K.,
Eichele D.D.,
Smith P.W.,
Bociek R.,
Akhtari M.,
Freifeld A.
Publication year - 2012
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12017
Subject(s) - medicine , fecal bacteriotherapy , clostridium difficile , fulminant , feces , hematopoietic stem cell transplantation , stem cell , transplantation , refractory (planetary science) , hematopoietic stem cell , gut flora , gastroenterology , immunology , haematopoiesis , microbiology and biotechnology , antibiotics , biology , genetics , astrobiology
We present a case of severe C lostridium difficile infection ( CDI ) in a non‐neutropenic allogeneic hematopoietic stem cell transplant recipient who was treated successfully with fecal microbiota therapy after standard pharmacologic therapy had failed. Following naso‐jejunal instillation of donor stool, the patient's symptoms resolved within 48 h. Bowel resection was averted. This is the first case in the literature, to our knowledge, to describe fecal microbiota therapy in a profoundly immunocompromised host with severe CDI . We propose that fecal microbiota therapy be considered as a therapeutic option in immunosuppressed patients with refractory severe CDI .