Premium
Efficient control of pandemic 2009 H1N1 virus infection with intravenous zanamivir despite the lack of immune function
Author(s) -
Ghosh S.,
Adams O.,
Schuster F.R.,
Borkhardt A.,
Meisel R.
Publication year - 2012
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/tid.12004
Subject(s) - zanamivir , medicine , immune system , immunology , pandemic , virus , aplasia , respiratory tract , haematopoiesis , bone marrow , influenza a virus , hematopoietic stem cell transplantation , immunity , virology , transplantation , stem cell , respiratory system , covid-19 , disease , biology , infectious disease (medical specialty) , genetics
A teenager who acquired 2009 H1N1 influenza A lower respiratory tract infection during total bone marrow and lymphoid aplasia, in the setting of human leukocyte antigen‐haploidentical hematopoietic stem cell transplantation, was successfully treated with intravenous zanamivir. This case demonstrates efficient control of pandemic influenza infection by intravenous zanamivir in the absence of any functional immune system, thus suggesting profound antiviral activity.