Open AccessAxillary lymph node dissection vs sentinel biopsy only among women with early‐stage breast cancer and sentinel node metastasis: A systematic review and meta‐analysis
Author(s) -
Peristeri Dimitra V.,
Harissis Haralampos V.
Publication year - 2021
Publication title -
the breast journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 72
eISSN - 1524-4741
pISSN - 1075-122X
DOI - 10.1111/tbj.14140
Subject(s) - medicine , axillary lymph node dissection , sentinel lymph node , breast cancer , sentinel node , stage (stratigraphy) , biopsy , oncology , surgery , radiology , cancer , paleontology , biology
Axillary lymph node dissection (ALND) in early‐stage breast cancer with limited sentinel node metastasis may not be superior to sentinel lymph node dissection (SLND). We performed a meta‐analysis comparing SLND/Radiotherapy (RT) with ALND. All data were analyzed using Review Manager Software 5.3. Five randomized controlled trials (RCTs) were included. Overall survival, death, and disease‐free survival were estimated higher in the SLND group compared to the ALND group. Statistically significant differences in axillary recurrence were observed in favor of ALND. Omission of ALND in patients with <3 positive SLNs is indicated.