Open AccessPrimary neuroendocrine carcinoma of the breast: A case report of liver and lymph node metastases after eight years from diagnosis
Author(s) -
Valente Irene,
Tringali Giulia,
Martella Eugenia Marta,
Pallavera Lara,
D'Aloia Cecilia
Publication year - 2020
Publication title -
the breast journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 72
eISSN - 1524-4741
pISSN - 1075-122X
DOI - 10.1111/tbj.13535
Subject(s) - medicine , synaptophysin , chromogranin a , lymph node , breast carcinoma , carcinoma , pathology , neuroendocrine carcinoma , oncology , mammography , neuroendocrine tumors , breast cancer , immunohistochemistry , cancer
Primary neuroendocrine carcinoma of the breast (NECB) is one of the rarest subtypes of breast tumor, and for this reason, there are no data from prospective clinical trials on its optimal management. Its incidence is <0.1% of all breast cancers and <1% of all neuroendocrine tumors. The diagnosis of NECB requires the expression of neuroendocrine markers (chromogranin, synaptophysin, NSE) and the lack of simultaneous neuroendocrine carcinoma in extramammary sites. We present a case of a poorly differentiated neuroendocrine carcinoma (PD‐NEC) metastasized in liver and lymph node after eight years. Mammography, ultrasound imaging, CT, and pathology findings are described.