Open AccessRelation between Hypofractionated Radiotherapy, Toxicity and Outcome in Early Breast Cancer
Author(s) -
De Felice Francesca,
Ranalli Tiziana,
Musio Daniela,
Lisi Roberto,
Rea Federica,
Caiazzo Rossella,
Tombolini Vincenzo
Publication year - 2017
Publication title -
the breast journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 72
eISSN - 1524-4741
pISSN - 1075-122X
DOI - 10.1111/tbj.12792
Subject(s) - medicine , common terminology criteria for adverse events , toxicity , breast cancer , radiation therapy , adjuvant , acute toxicity , dose fractionation , oncology , adverse effect , cancer , urology , surgery
To compare adjuvant conventional radiotherapy (C‐ RT ) to hypofractionated schedule ( HF ‐ RT ) in early breast cancer. Between May 2012 and September 2015, 120 patients were included in the analysis. All patients underwent conservative surgery and adjuvant RT . RT was delivered in C‐ RT (50 Gy; 2 Gy/fr) or HF ‐ RT (42.5 Gy; 2.66 Gy/fr), followed by a tumor bed boost (10 Gy; 2 Gy/fr). RT ‐induced toxicity was recorded and compared between groups. Toxicity results were graded according to the Common Terminology Criteria for Adverse Events guidelines. A multivariate analysis was performed of the factors associated with acute toxicity onset. Mild acute skin toxicity was observed in 71.7% of patients. No grade 4 toxicity was observed. From the multivariate analysis, Breast volume and RT fractionation significantly affected acute radiation‐related toxicity. No increase in late toxic effects has been reported between C‐ RT and HF ‐ RT schedules. Overall, the 2‐year disease free survival was 94.4%. HF ‐ RT represents a valid adjuvant treatment option in early breast cancer patients, without negative impact on acute and late radiation sequelae, as well as tumor control.