Open AccessManagement of Early Node‐Positive Breast Cancer in Australia: A Multicentre Study
Author(s) -
Gannan Emma,
Khoo Jeremy,
Nightingale Sophie,
Suhardja Thomas Surya,
Lippey Jocelyn,
Keane Holly,
Tan Kian Jin,
Clouston David,
Gorelik Alexandra,
Mann Gregory Bruce
Publication year - 2016
Publication title -
the breast journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 72
eISSN - 1524-4741
pISSN - 1075-122X
DOI - 10.1111/tbj.12595
Subject(s) - medicine , axillary lymph node dissection , breast cancer , sentinel node , micrometastasis , sentinel lymph node , axilla , cancer , biopsy , surgery , radiology
Abstract To examine practice patterns for breast cancer patients with limited sentinel node ( SN ) disease in light of the ACOSOG Z0011 results. Retrospective analysis of patients with T1‐2 breast cancer and positive sentinel lymph node biopsy ( SLNB ) admitted between January 2009 and December 2012. Patient demographics, tumor characteristics, and treatments were recorded. Eight hundred positive SLNB s were identified. A total of 452 (56.5%) proceeded to completion axillary lymph node dissection ( cALND ). cALND rate decreased from 65.1% to 49.7% from 2009–2010 to 2011–2012. cALND was performed for micrometastasis or isolated tumor cells in 39.3% in 2009–2010 and 22.2% in 2011–2012, whereas for macrometastases the rates were 83.1% and 68.6%, respectively. cALND rates diminished for both Z0011‐eligible and ‐ineligible patients. The ACOSOG Z0011 trial presentation and publication coincided with a reduction in cALND for breast cancer with limited nodal disease. There appears equipoise regarding management of macrometastatic SN disease.