Open AccessSurgical Decision Making in the BRCA ‐Positive Population: Institutional Experience and Comparison with Recent Literature
Author(s) -
FlippoMorton Teresa,
Walsh Kendall,
Chambers Karinn,
AmackerNorth Lisa,
White Brook,
Sarantou Terry,
Boselli Danielle M.,
White Richard L.
Publication year - 2015
Publication title -
the breast journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 72
eISSN - 1524-4741
pISSN - 1075-122X
DOI - 10.1111/tbj.12521
Subject(s) - medicine , brca mutation , population , mastectomy , retrospective cohort study , breast cancer , cancer , genetic testing , oncology , surgery , gynecology , environmental health
A retrospective study was performed to document the uptake and extent of surgical intervention in patients with a known mutation in the BRCA 1/2 genes and associated outcomes. Data were collected retrospectively on BRCA ‐positive patients with and without cancer at the time of genetic testing. Our findings were compared to those published in the current literature. Of patients with cancer at testing, 61% chose bilateral mastectomies. Of patients without cancer, 54% chose risk‐reducing surgery ( RRS ) including risk‐reducing mastectomy ( RRM ), risk‐reducing salpingo‐oophorectomy ( RRSO ), or both. Time to surgery was significantly shorter to RRSO than to RRM . The literature suggests and our data support that acceptance of RRM in the BRCA ‐positive population has gradually increased over time. Consistently high rates of RRSO uptake and short intervals from time‐of‐testing to RRSO demonstrate that RRSO is still more acceptable to this population than RRM .