
Is There a Role for Oncotype Dx Testing in Invasive Lobular Carcinoma?
Author(s) -
Conlon Niamh,
Ross Dara S.,
Howard Jane,
Catalano Jeffrey P.,
Dickler Maura N.,
Tan Lee K.
Publication year - 2015
Publication title -
the breast journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 72
eISSN - 1524-4741
pISSN - 1075-122X
DOI - 10.1111/tbj.12445
Subject(s) - medicine , invasive lobular carcinoma , estrogen receptor , immunohistochemistry , oncology , breast cancer , lobular carcinoma , regimen , cancer , ductal carcinoma , invasive ductal carcinoma
Oncotype Dx Breast Cancer Assay is a 21‐gene assay used in estrogen receptor ( ER )‐positive breast cancer to predict benefit from chemotherapy (CT). Tumors are placed into one of three risk categories based on their recurrence score ( RS ). This paper explores the impact of tumor histopathologic features and Oncotype Dx RS on the treatment plan for invasive lobular carcinoma ( ILC ). Invasive lobular carcinoma cases submitted for Oncotype Dx testing were identified from a clinical data base. The histopathologic and immunohistochemical features and RS subcategory of each tumor, and treatment regimen and medical oncologic assessments of each patient were reviewed. A total of 135 cases of ILC had RS testing, which represented 15% of all ILC diagnosed at the institution over the time period. 80% of ILC was of the classical subtype and all tumors were ER positive and human epidermal growth factor receptor 2 (HER‐2) negative by immunohistochemistry. Sixty three percent of cases were low risk ( LR ), 35.5% were intermediate risk ( IR ) and 1.5% were high risk ( HR ). Both HR cases were pleomorphic ILC . Sixty eight percent of classical ILC had a LR score, while 70% of pleomorphic ILC had an IR score. Patients in the IR category were significantly more likely to undergo CT than patients in the LR category (54% versus 18%; p < 0.0001). In the LR category, those undergoing CT were significantly younger and more likely to have positive lymph nodes (p < 0.05). Qualitative analysis of medical oncologic assessments showed that RS played a role in decision‐making on CT in 74% of cases overall. At our institution, Oncotype Dx RS currently plays a role in the management of a proportion of ILC and impacts on treatment decisions.