Open AccessMalignant Adenomyoepithelioma of the Breast: A Review
Author(s) -
Ahmadi Nasrollah,
Negahban Shahrzad,
Aledavood Azita,
Daneshbod Khosrow,
Daneshbod Yahya
Publication year - 2015
Publication title -
the breast journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 72
eISSN - 1524-4741
pISSN - 1075-122X
DOI - 10.1111/tbj.12390
Subject(s) - myoepithelial cell , medicine , pleomorphism (cytology) , malignancy , pathology , immunohistochemistry , lesion , histology , cytology , population , environmental health
Malignant adenomyoepithelioma ( MAME ) of the breast is a rare lesion characterized by dual population of epithelial and myoepithelial cells which one or both components show malignant features. We report a case of MAME of the breast in a 46‐year‐old woman diagnosed by fine‐needle aspiration with extensive review of the literature. Classification, clinical presentation, cyto‐pathologic, and immunohistochemical features are described. This lesion showed both malignant components of epithelial and myoepithelial cells in cytology and histology. The malignancy was convincingly supported by high mitotic figures, pleomorphism, and invasion in tissue sections. This review of MAME s showed that cyto‐histologic diagnosis is difficult and should be supported by immunohistochemical study.