Open AccessLandmark Clinical Trials Influencing Surgical Management of Non‐invasive and Invasive Breast Cancer
Author(s) -
Julian Thomas B.,
Venditti Charis A.,
Duggal Shivani
Publication year - 2014
Publication title -
the breast journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.533
H-Index - 72
eISSN - 1524-4741
pISSN - 1075-122X
DOI - 10.1111/tbj.12363
Subject(s) - medicine , cosmesis , breast cancer , clinical trial , radiation therapy , mastectomy , cancer , quality of life (healthcare) , general surgery , intensive care medicine , surgery , nursing
The surgical management of breast cancer has changed considerably since the use of the Halstedian radical mastectomy early in the 20th century. Over the last 50 years, several landmark clinical trials from the USA and E urope have resulted in a paradigm shift in the management of breast cancer toward less radical forms of surgery with the combined use of multi‐modality treatments including systemic chemotherapy, endocrine therapy, and radiotherapy. Advances in such research have established a new worldwide standard of care for breast cancer surgical management and treatment, which has become more patient centric and which places a higher emphasis on cosmesis and improved patient quality of life. In this chapter, we review the landmark clinical trials that have influenced surgical management for non‐invasive and invasive breast cancer and that serve to guide current clinical practices to date.