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Mitigating the risk of African swine fever virus in feed with anti‐viral chemical additives
Author(s) -
Niederwerder Megan C.,
Dee Scott,
Diel Diego G.,
Stoian Ana M. M.,
Constance Laura A.,
Olcha Matthew,
Petrovan Vlad,
Patterson Gilbert,
CinoOzuna Ada G.,
Rowland Raymond R. R.
Publication year - 2021
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.13699
Subject(s) - african swine fever virus , african swine fever , animal feed , infectivity , limiting , virus , biology , food science , virology , microbiology and biotechnology , mechanical engineering , engineering
African swine fever (ASF) is currently considered the most significant global threat to pork production worldwide. Disease caused by the ASF virus (ASFV) results in high case fatality of pigs. Importantly, ASF is a trade‐limiting disease with substantial implications on both global pork and agricultural feed commodities. ASFV is transmissible through natural consumption of contaminated swine feed and is broadly stable across a wide range of commonly imported feed ingredients and conditions. The objective of the current study was to investigate the efficacy of medium‐chain fatty acid and formaldehyde‐based feed additives in inactivating ASFV. Feed additives were tested in cell culture and in feed ingredients under a transoceanic shipment model. Both chemical additives reduced ASFV infectivity in a dose‐dependent manner. This study provides evidence that chemical feed additives may potentially serve as mitigants for reducing the risk of ASFV introduction and transmission through feed.