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γδ T cells in livestock: Responses to pathogens and vaccine potential
Author(s) -
Baldwin Cynthia L.,
Yirsaw Alehegne,
Gillespie Alexandria,
Le Page Lauren,
Zhang Fengqiu,
DamaniYokota Payal,
Telfer Janice C.
Publication year - 2020
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.13328
Subject(s) - biology , innate immune system , immune system , acquired immune system , immunology , immunity , interferon
The immediate objective of our research is to understand the molecular mechanisms underlying activation and potentiation of the protective functional response of WC 1 + γδ T cells to pathogens afflicting livestock species. The long‐term goal is to incorporate stimulation of these cells into the next generation of vaccine constructs. γδ T cells have roles in the immune response to many infectious diseases including viral, bacterial, protozoan and worm infections, and their functional responses overlap with those of canonical αβ T cells, for example they produce cytokines including interferon‐γ and IL ‐17. Stimulation of non‐conventional lymphocytes including γδ T cells and αβ natural killer T ( NKT ) cells has been shown to contribute to protective immunity in mammals, bridging the gap between the innate and adaptive immune responses. Because of their innate‐like early response, understanding how to engage γδ T‐cell responses has the potential to optimize strategies of those that aim to induce pro‐inflammatory responses as discussed here.