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Genome comparison of African swine fever virus China/2018/Anhui XCGQ strain and related European p72 Genotype II strains
Author(s) -
Bao Jingyue,
Wang Qinghua,
Lin Peng,
Liu Chunju,
Li Lin,
Wu Xiaodong,
Chi Tianying,
Xu Tiangang,
Ge Shengqiang,
Liu Yutian,
Li Jinming,
Wang Shujuan,
Qu Hailong,
Jin Tao,
Wang Zhiliang
Publication year - 2019
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.13124
Subject(s) - biology , genotype , genome , strain (injury) , whole genome sequencing , phylogenetic tree , virulence , gene , genetics , genetic diversity , genetic variation , virology , population , anatomy , demography , sociology
Summary African swine fever was introduced into China in August 2018 and led to high mortality in domestic pigs. We reported the genome characterization of the China/2018/Anhui XCGQ strain mainly based on next‐generation sequencing and comparison with related European p72 Genotype II strains. The genome was 189,393 bp long, encoding 181 open reading frames. Pair‐wise genome sequence comparison revealed 54–107 variation sites between China/2018/Anhui XCGQ and the other genotype II virulent strains contributing to the change of expression or alteration of amino acid residues in 10–38 genes. China/2018/Anhui XCGQ strain shared the highest similarity with POL /2015/Podlaskie strain. Phylogenetic analysis based on a 125 kb long conserved central region revealed that the China/2018/Anhui XCGQ strain and four European genotype II strains were grouped into three clusters. This study expanded our knowledge on the genetic diversity and evolution of ASFV and provided valuable information for diagnosis improvement and vaccine development.