Premium
Diversified sources for human infections by Salmonella enterica serovar newport
Author(s) -
Pan Hang,
Zhou Xin,
Chai Wenqin,
Paudyal Narayan,
Li Shuning,
Zhou Xiao,
Zhou Kun,
Wu Qingqing,
Wu Beibei,
Li Guogang,
Rajkovic Andreja,
Fang Weihuan,
Rankin Shelley C.,
Li Yan,
Xu Xuebin,
Schifferli Dieter M.,
Yue Min
Publication year - 2019
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.13099
Subject(s) - multilocus sequence typing , salmonella enterica , biology , genotyping , salmonella , serotype , phylogenetic tree , antibiotic resistance , genotype , resistome , microbiology and biotechnology , genetic diversity , multiple drug resistance , typing , phylogenetic diversity , drug resistance , human pathogen , antibiotics , genetics , bacteria , gene , integron , medicine , population , environmental health
Salmonella enterica Newport ( S . Newport), with phylogenetic diversity feature, contributes to significant public health concerns. Our previous study suggested that S . Newport from multiple animal‐borne routes, with distinct antibiotic resistant pattern, might transmit to human. However, their genetic information was lacking. As a complement to the earlier finding, we investigate the relationship between each other among the hosts, sources, genotype and antibiotic resistance in S . Newport. We used the multilocus sequence typing (MLST) in conjunction with minimum inhibitory concentration of 16 antibiotics of globally sampled 1842 S . Newport strains, including 282 newly contributed Chinese strains, to evaluate this association. Our analysis reveals that sequence types (STs) are significantly associated with different host sources, including livestock (ST45), birds (ST5), contaminated water and soil (ST118), reptiles (ST46) and seafood (ST31). Importantly, ST45 contained most of (344/553) the multi‐drug resistance (MDR) strains, which were believed to be responsible for human MDR bacterial infections. Chinese isolates were detected to form two unique lineages of avian (ST808 group) and freshwater animal (ST2364 group) origin. Taken together, genotyping information of S . Newport could serve to improve Salmonella source‐originated diagnostics and guide better selection of antibiotic therapy against Salmonella infections.