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Genetic diversity of porcine circovirus type 2 in China between 1999–2017
Author(s) -
Wang Huijuan,
Gu Jinyan,
Xing Gang,
Qiu Xiaohuo,
An Shuting,
Wang Yuexia,
Zhang Cheng,
Liu Changming,
Gong Wenjie,
Tu Changchun,
Su Shuo,
Zhou Jiyong
Publication year - 2019
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.13040
Subject(s) - porcine circovirus , genetic diversity , circovirus , biology , genotype , china , genetics , genetic variation , gene , evolutionary biology , virology , virus , demography , population , geography , archaeology , sociology
Porcine circovirus type 2 ( PCV ‐2), is linked to PCV ‐2 associated disease, which has caused considerable economic loss in the swine industry. Here, we report the genetic diversity of PCV ‐2 in China. A total of 74 Chinese PCV ‐2 strains sequenced between 1999 and 2017 were studied. Based on the ORF 2 and complete genomes, we found that apart from the PCV ‐2a, PCV ‐2b, and PCV ‐2d genotypes, two unstable recombination genotypes also exist, referred to as IM 1 and IM 2 genotypes. We found that the patterns of PCV ‐2 genetic shift in China are similar to the patterns at the global level. Additionally, for the PCV ‐2 ORF 2 gene of Chinese isolates, we found a similar time to the most recent common ancestor and evolutionary rate to the global values. This indicates that PCV 2 genetic diversity in China is driven by genetic drift/recombination of local strains and by the sporadic introduction of foreign genotypes from other countries. Overall, our study illustrates the genetic diversity and evolution dynamics of PCV ‐2 in China.