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A novel NADC 30‐like porcine reproductive and respiratory syndrome virus ( PRRSV ) plays a limited role in the pathogenicity of porcine circoviruses ( PCV 2 and PCV 3) and PRRSV co‐infection
Author(s) -
Chen Nanhua,
Li Shuai,
Ye Mengxue,
Huang Yucheng,
Huang Ya,
Xiao Yanzhao,
Yu Xiao,
Dong Jianbao,
Tian Kegong,
Zhu Jianzhong
Publication year - 2019
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.13026
Subject(s) - porcine reproductive and respiratory syndrome virus , biology , virology , pathogenicity , virus , microbiology and biotechnology
Co‐infection of porcine reproductive and respiratory syndrome virus ( PRRSV ) and porcine circoviruses ( PCV s) is commonly observed under field conditions and elicits more severe diseases than any singular infection. In this study, the co‐infection of PRRSV , PCV 2 and PCV 3 was analyzed in tissue samples collected from 150 pigs from April 2016 to April 2018. PRRSV , PCV 2 and PCV 3 was detected in 55 (36.67%), 43 (28.67%) and 3 (2%) of 150 pigs respectively. Remarkably, one lung sample ( SD 17‐36) collected from a diseased pig was co‐infected with PRRSV , PCV 2 and PCV 3. The complete genomes of SD 17‐36 viruses of PRRSV , PCV 2 and PCV 3 were determined, which belong to the subgroups of NADC 30‐like PRRSV , PCV 2d and PCV 3a respectively. Sequence comparison showed that PRRSV SD 17‐36 isolate contains a N33 deletion in GP 5. Animal challenge study showed that the novel NADC 30‐like PRRSV SD 17‐36 isolate is low pathogenic. Our results indicate that the co‐infection of PRRSV and PCV s might cause diseases even when PRRSV plays a limited role in the pathogenicity of the co‐infection.