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Molecular characterization of whole genome sequence of infectious bronchitis virus 624I genotype confirms the close relationship with Q1 genotype
Author(s) -
Laconi Andrea,
Listorti Valeria,
Franzo Giovanni,
Cecchinato Mattia,
Naylor Clive,
Lupini Caterina,
Catelli Elena
Publication year - 2019
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.13000
Subject(s) - genotype , phylogenetic tree , biology , genetics , gene , genome , avian infectious bronchitis virus , virology , infectious bronchitis virus , sequence analysis , whole genome sequencing , phylogenetics , avian infectious bronchitis , covid-19 , infectious disease (medical specialty) , medicine , disease , pathology
Infectious Bronchitis virus ( IBV ) genotype Q1 was detected for the first time in China in 1996, and then spread worldwide. The first report of Q1 genotype in Italy occurred in 2011 and a deep molecular investigation of a Q1 isolated in Italy in 2013 has led to speculation regarding the origin of this genotype. Phylogenetic analysis of the S1 sequence of a Q1 Italian strain revealed a close relationship with sequences of the 624I strains circulating in Italy in the early 1990s and this led to the idea that 624I was an ancestor of the Q1 genotype. Despite the fact that most heterogeneity of IBV s occurs in the S1 gene, the sequence analysis of this gene alone was not sufficient to confirm or deny this hypothesis. In the present study, an Italian 624I (gammaCoV/AvCov/Ck/Italy/ IP 14425/96) was fully sequenced for the first time and compared to all available complete Q1 genome sequences. This analysis confirmed the genetic correlation between GammaCoV/AvCov/Ck/Italy/ IP 14425/96 and Q1 strains, suggesting a common origin between 624I and Q1 genotypes.