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Identification and genomic characterization of influenza viruses with different origin in Mexican pigs
Author(s) -
SaavedraMontañez Manuel,
Vaca Luis,
RamírezMendoza Humberto,
GaitánPeredo Carmen,
BautistaMartínez Rebeca,
SeguraVelázquez René,
CervantesTorres Jacquelynne,
SánchezBetancourt José Ivan
Publication year - 2019
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.12998
Subject(s) - biology , virus , virology , h5n1 genetic structure , genome , population , influenza a virus , influenza a virus subtype h5n1 , antigenic shift , genetics , gene , disease , antigenic drift , covid-19 , infectious disease (medical specialty) , medicine , environmental health , pathology
Swine influenza is a worldwide disease, which causes damage to the respiratory system of pigs. The H1N1 and H3N2 subtypes circulate mainly in the swine population of Mexico. There is evidence that new subtypes of influenza virus have evolved genetically and have been rearranged with human viruses and from other species; therefore, the aim of our study was to identify and characterize the genetic changes that have been generated in the different subtypes of the swine influenza virus in Mexican pigs. By sequencing and analyzing phylogenetically the eight segments that form the virus genome, the following subtypes were identified: H1N1, H3N2, H1N2 and H5N2; of which, a H1N1 subtype had a high genetic relationship with the human influenza virus. In addition, a H1N2 subtype related to the porcine H1N2 virus reported in the United States was identified, as well as, two other viruses of avian origin from the H5N2 subtype. Particularly for the H5N2 subtype, this is the first time that its presence has been reported in Mexican pigs. The analysis of these sequences demonstrates that in the swine population of Mexico, circulate viruses that have suffered punctual‐specific mutations and rearrangements of their proteins with different subtypes, which have successfully adapted to the Mexican swine population.