Premium
Full‐length genome sequence analysis of an avian leukosis virus subgroup J (ALV‐J) as contaminant in live poultry vaccine: The commercial live vaccines might be a potential route for ALV ‐J transmission
Author(s) -
Wang P.,
Lin L.,
Li H.,
Shi M.,
Gu Z.,
Wei P.
Publication year - 2018
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.12841
Subject(s) - virology , biology , genome , sequence (biology) , virus , genetics , gene
Summary One avian leukosis virus subgroup J ( ALV ‐J) strain was isolated from 67 commercial live poultry vaccines produced by various manufacturers during 2013–2016 in China. The complete genomes of the isolate were sequenced and it was found that the genes gag and pol of the strain were relatively conservative, while the gp85 gene of the strain GX 14 YYA 1 had the highest similarities with a field strain GX 14 ZS 14, which was isolated from the chickens of a farm that had once used the same vaccine as the one found to be contaminated with the GX 14 YYA 1. This is the first report of ALV ‐J contaminant in live poultry vaccine in China. Our finding demonstrates that vaccination of the commercial live vaccines might be a potential new route for ALV ‐J transmission in chickens and highlights the need for more extensive monitoring of the commercial live vaccines in China.