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Retrospective study of porcine circovirus type 2 infection reveals a novel genotype PCV 2f
Author(s) -
Bao F.,
Mi S.,
Luo Q.,
Guo H.,
Tu C.,
Zhu G.,
Gong W.
Publication year - 2018
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.12721
Subject(s) - porcine circovirus , genotype , biology , phylogenetic tree , virology , circovirus , clade , genetic diversity , genetics , virus , gene , medicine , population , environmental health
Summary Porcine postweaning multisystemic wasting syndrome ( PMWS ) caused by porcine circovirus type 2 ( PCV 2) is a disease causing severe economic losses annually worldwide to the pig industry. PCV 2 infection was first reported in China in 2000, and currently has three major genotypes, PCV 2a, b and d, circulating in this country. To further elucidate the origin and prevalence of PCV 2 in China, 123 clinical pig tissue samples collected in 25 provinces between 1990 and 1999 were analysed by PCV 2‐specific PCR , resulting in identification of 23 PCV 2 strains collected between 1996 and 1999. Phylogenetic analysis based on the nucleotide sequences of open reading frame 2 ( ORF 2) showed that 20 of the 23 grouped within PCV 2a, while the remaining three strains formed an independent clade, so far unreported and therefore named PCV 2f. This genotype shared lower sequence identity with other known genotypes. This study provides further understanding of the genetic diversity and evolution of PCV 2 and has tracked PCV 2 infection in China back to 1996 rather than 2000.