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Phylogenetic and genomic characterization of a novel atypical porcine pestivirus in China
Author(s) -
Zhang H.,
Wen W.,
Hao G.,
Hu Y.,
Chen H.,
Qian P.,
Li X.
Publication year - 2018
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.12675
Subject(s) - pestivirus , phylogenetic tree , genbank , biology , genome , homology (biology) , virology , whole genome sequencing , genetics , phylogenetics , gene , virus , flaviviridae , viral disease
Summary Atypical porcine pestivirus ( APPV ) has been considered a novel pestivirus and causative agent of congenital tremor type A‐ II . An APPV CH ‐ GX 2016 strain was characterized from newly born piglets with clinical symptoms of congenital tremor in Guangxi, China. The genome of APPV CH ‐ GX 2016 strain was 11,475 bp in length and encoded a polyprotein composed of the 3,635 amino acids. This genome sequence exhibited 88.0% to 90.8% nucleotide sequence homology with other APPV reference sequences in GenBank. Phylogenetic analysis further showed that APPV CH ‐ GX is a novel pestivirus compared with previously described classical pestivirus strains. Therefore, APPV is present in pigs in China.