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Tuberculosis Caused by Mycobacterium orygis in Dairy Cattle and Captured Monkeys in Bangladesh: a New Scenario of Tuberculosis in South Asia
Author(s) -
Rahim Z.,
Thapa J.,
Fukushima Y.,
Zanden A. G. M.,
Gordon S. V.,
Suzuki Y.,
Nakajima C.
Publication year - 2017
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.12596
Subject(s) - multiple loci vntr analysis , biology , variable number tandem repeat , tuberculosis , mycobacterium bovis , typing , mycobacterium tuberculosis , tandem repeat , veterinary medicine , subspecies , virology , genotype , microbiology and biotechnology , genetics , zoology , gene , medicine , genome , pathology
Summary Mycobacterium orygis , commonly known as the oryx bacillus and a newly proposed Mycobacterium tuberculosis complex subspecies, was isolated from 18 cattle in a dairy farm and two captured rhesus monkeys in a zoo in Bangladesh. All the infected animals had tuberculosis lesions in their lungs, suggesting transmission and infection with M. orygis by an airborne route. The 20 isolates were analysed using a range of conventional and molecular typing methods, and RD ‐deletion typing and sequencing of selected genes confirmed the isolates as M. orygis . Multiple‐locus variable‐number tandem repeat analysis ( MLVA ) allowed the isolates to be divided into three clusters based on the relatedness of their MLVA profiles. The two monkey isolates shared the same MLVA pattern with 15 of the cattle isolates, whereas the remaining three cattle isolates had different patterns, even though the latter animals had been kept in the same dairy farm. The diversity observed among isolates may suggest the bacteria have been established in this area for a long period. This study along with other recent findings that report the detection of M. orygis from animals as well as humans originating from South Asia potentially indicate endemic distribution of M. orygis in South Asia.