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Two Commercial Type 1 Porcine Reproductive and Respiratory Syndrome Virus ( PRRSV )‐Modified Live Vaccines Reduce Seminal Shedding of Type 1 PRRSV but not Type 2 PRRSV in Infected Boars
Author(s) -
Park C.,
Kim T.,
Choi K.,
Jeong J.,
Kang I.,
Park S.J.,
Chae C.
Publication year - 2017
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.12361
Subject(s) - porcine reproductive and respiratory syndrome virus , viremia , virology , biology , semen , viral shedding , vaccination , virus , genetics
Summary The objective of this study was to compare the effects of two commercial type 1 porcine reproductive and respiratory syndrome virus ( PRRSV )‐modified live vaccines on type 1 and type 2 PRRSV shedding in the semen of experimentally infected boars. Upon challenge with PRRSV , unvaccinated boars exhibited an increase in daily rectal temperature (39.4–39.7°C). Vaccination of boars with type 1 PRRSV significantly reduced the amount of type 1 PRRSV load in blood and semen after challenge with type 1 PRRSV , but barely reduced the amount of type 2 PRRSV load in blood and semen after the type 2 PRRSV challenge. There were no significant differences in the reduction of viremia and seminal shedding of type 1 and type 2 PRRSV between the two commercial vaccines. The seminal shedding of PRRSV is independent of viremia. The reduction of type 1 PRRSV seminal shedding coincided with the appearance of type 1 PRRSV ‐specific interferon‐γ secreting cells ( IFN ‐γ‐ SC ) in vaccinated type 1 PRRSV ‐challenged boars. The frequencies of type 1 PRRSV ‐specific IFN ‐γ‐ SC induced by type 1 PRRSV vaccine are relatively high compared to type 2 PRRSV ‐specific IFN ‐γ‐ SC induced by the same vaccine which may explain why type 1 PRRSV vaccine is more effective in reducing seminal shedding of type 1 PRRSV when compared to type 2 PRRSV in vaccinated challenged boars. These results provide clinical information on how to reduce seminal shedding of type 1 PRRSV in boars using type 1 PRRSV ‐modified live vaccine.